Comparison of effects of adjuvants on efficacy of virion envelope herpes simplex virus vaccine against labial infection of BALB/c mice.

摘要: Abstract A subunit virion envelope vaccine of herpes simplex virus type 1 was evaluated for its ability to protect labially infected mice from development the primary herpetic lesion, encephalitic death, and latent infection in trigeminal ganglion. Several adjuvants, including aluminum hydroxide polyriboinosinic acid-polyribocytidylic acid complexed with poly-L-lysine carboxymethyl cellulose were investigated their enhance protection compared effectiveness complete Freund adjuvant. The demonstrated be immunogenic, as shown by antibody detectable an enzyme-linked immunosorbent assay. humoral immune response correlated encephalitis and, at a lower degree, prevention appearance lesions acceleration lesion resolution. efficacy most apparent protecting death. To reduce or prevent difficult, but achieved some regimens. Repeated administrations adjuvant required this protection. effective adjuvant, several synthetic adjuvants effective, particularly polyriboinosinic-polyribocytidylic acid-poly-L-lysine-carboxymethyl immunoadjuvant.