Optogenetic control of the enteric nervous system and gastrointestinal transit.
作者： Nick J Spencer , Tim Hibberd , Jing Feng , Hongzhen Hu
DOI: 10.1080/17474124.2019.1581061
关键词:
摘要: Introduction: There are limited effective therapies available for improving gastrointestinal (GI) transit in mammals with intractable or chronic constipation. Current therapeutics to improve GI-transit usually require oral ingestion of therapeutic drugs, such as the serotonin receptor agonist prucalopride. However, most receptors distributed all over body and unsurprisingly drugs like prucalopride stimulate multiple organs, often leading unwanted side effects. is a desperate need community selectively without effects on other organs.Areas covered: We performed systematic review literature Pubmed report significant technical advances optogenetic control GI-tract. discuss recent demonstrations that optogenetics can be used potently activity subsets enteric neurons. Special focus made first demonstration wireless colon conscious, freely-mov...
sci-hub.se 参考文章(30)
N. J. Spencer, R. A. Bywater, Enteric nerve stimulation evokes a premature colonic migrating motor complex in mouse Neurogastroenterology and Motility. ,vol. 14, pp. 657- 665 ,(2002) , 10.1046/J.1365-2982.2002.00367.X
Sara E. Gombash, Christopher J. Cowley, Julie A. Fitzgerald, Jodie C. E. Hall, Christian Mueller, Fedias L. Christofi, Kevin D. Foust, Intravenous AAV9 efficiently transduces myenteric neurons in neonate and juvenile mice Frontiers in Molecular Neuroscience. ,vol. 7, pp. 81- 81 ,(2014) , 10.3389/FNMOL.2014.00081
Shrivats Mohan Iyer, Kate L Montgomery, Chris Towne, Soo Yeun Lee, Charu Ramakrishnan, Karl Deisseroth, Scott L Delp, Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice. Nature Biotechnology. ,vol. 32, pp. 274- 278 ,(2014) , 10.1038/NBT.2834
Jackie D. Wood, Enteric Nervous System: The Brain-in-the-Gut ,(2011)
Brian Y. Chow, Xue Han, Allison S. Dobry, Xiaofeng Qian, Amy S. Chuong, Mingjie Li, Michael A. Henninger, Gabriel M. Belfort, Yingxi Lin, Patrick E. Monahan, Edward S. Boyden, High-performance genetically targetable optical neural silencing by light-driven proton pumps Nature. ,vol. 463, pp. 98- 102 ,(2010) , 10.1038/NATURE08652
Georg Nagel, Doris Ollig, Markus Fuhrmann, Suneel Kateriya, Anna Maria Musti, Ernst Bamberg, Peter Hegemann, Channelrhodopsin-1: A Light-Gated Proton Channel in Green Algae Science. ,vol. 296, pp. 2395- 2398 ,(2002) , 10.1126/SCIENCE.1072068
M. Costa, S.J.H. Brookes, P.A. Steeled, I. Gibbins, E. Burcher, C.J. Kandiah, Neurochemical classification of myenteric neurons in the guinea-pig ileum. Neuroscience. ,vol. 75, pp. 949- 967 ,(1996) , 10.1016/0306-4522(96)00275-8
JohnB. Furness, HeatherL. Robbins, Junhua Xiao, MartinJ. Stebbing, Kulmira Nurgali, Projections and chemistry of Dogiel type II neurons in the mouse colon. Cell and Tissue Research. ,vol. 317, pp. 1- 12 ,(2004) , 10.1007/S00441-004-0895-5
Matthew J Benskey, Nathan C Kuhn, James J Galligan, Joanna Garcia, Shannon E Boye, William W Hauswirth, Christian Mueller, Sanford L Boye, Fredric P Manfredsson, Targeted Gene Delivery to the Enteric Nervous System Using AAV: A Comparison Across Serotypes and Capsid Mutants Molecular Therapy. ,vol. 23, pp. 488- 500 ,(2015) , 10.1038/MT.2015.7
John Y. Lin, A user's guide to channelrhodopsin variants: features, limitations and future developments Experimental Physiology. ,vol. 96, pp. 19- 25 ,(2011) , 10.1113/EXPPHYSIOL.2009.051961