Methylation in Colorectal Cancer

摘要: Colorectal cancer (CRC) is the third most common worldwide, but age-standardized incidence rates (ASRs) vary widely between different geographical regions. Distinct epidemiological and clinicopathological characteristics of CRCs based on their specific molecular profiles suggest risk factors pathways transformation associated with colon carcinogenesis. Epigenetic events have been involved in stepwise histological progression CRC. Evidence for a mechanistic link DNA methylation histone deacetylation has also demonstrated by treating cells combination methyltransferase inhibitor deacetylase inhibitor. However, intrinsic environmental that induce changes remain largely unknown. Therefore, this chapter, our aim to define including patterns hypermethylation important candidate genes, polymorphism mutation genes CRC studies, relatively genetic compared Western countries. In addition, study human disease represents an frontier medicine. Furthermore, CpG islands very cells, coupled ability detect high degree sensitivity, led development several approaches detection body fluids. Comparison gene or protein expression types should reveal fascinating insights into mechanisms Molecular profiling epigenetic alteration will eventually allow chemoresponsive patients be identified much greater accuracy.