Inhibition of MAN2A1 Enhances the Immune Response to Anti-PD-L1 in Human Tumors.
作者： Sailing Shi , Shengqing Gu , Tong Han , Wubing Zhang , Lei Huang
DOI: 10.1158/1078-0432.CCR-20-0778
关键词:
摘要: … Pharmacologic inhibition of MAN2A1 by swainsonine, an indolizidine alkaloid that can be tolerated by patients with cancer, synergized with anti–PD-L1 in the treatment of melanoma …
aacrjournals.org
scilit.net参考文章(85)
Andrew J Gentles, Aaron M Newman, Chih Long Liu, Scott V Bratman, Weiguo Feng, Dongkyoon Kim, Viswam S Nair, Yue Xu, Amanda Khuong, Chuong D Hoang, Maximilian Diehn, Robert B West, Sylvia K Plevritis, Ash A Alizadeh, The prognostic landscape of genes and infiltrating immune cells across human cancers Nature Medicine. ,vol. 21, pp. 938- 945 ,(2015) , 10.1038/NM.3909
Salomé S. Pinho, Celso A. Reis, Glycosylation in cancer: mechanisms and clinical implications Nature Reviews Cancer. ,vol. 15, pp. 540- 555 ,(2015) , 10.1038/NRC3982
Stefani Spranger, Riyue Bao, Thomas F. Gajewski, Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity Nature. ,vol. 523, pp. 231- 235 ,(2015) , 10.1038/NATURE14404
Jonathan J. Lyons, Joshua D. Milner, Sergio D. Rosenzweig, Glycans Instructing Immunity: The Emerging Role of Altered Glycosylation in Clinical Immunology Frontiers in Pediatrics. ,vol. 3, pp. 54- 54 ,(2015) , 10.3389/FPED.2015.00054
Francesco M. Marincola, Elizabeth M. Jaffee, Daniel J. Hicklin, Soldano Ferrone, Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Advances in Immunology. ,vol. 74, pp. 181- 273 ,(2000) , 10.1016/S0065-2776(08)60911-6
P E Goss, C L Reid, D Bailey, J W Dennis, Phase IB clinical trial of the oligosaccharide processing inhibitor swainsonine in patients with advanced malignancies. Clinical Cancer Research. ,vol. 3, pp. 1077- 1086 ,(1997)
Jose Baptiste, Paul E. Goss, Michael Baker, James W. Dennis, Berny Fernandes, A Phase I Study of Swainsonine in Patients with Advanced Malignancies Cancer Research. ,vol. 54, pp. 1450- 1457 ,(1994)
Lieping Chen, Xue Han, Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future Journal of Clinical Investigation. ,vol. 125, pp. 3384- 3391 ,(2015) , 10.1172/JCI80011
Kamal Ishak, Amelia Baptista, Leonardo Bianchi, Francesco Callea, Jan De Groote, Fred Gudat, Helmut Denk, Valeer Desmet, Gerhard Korb, Roderick N.M. MacSween, M.James Phillips, Bernard G. Portmann, Hemming Poulsen, Peter J. Scheuer, Martin Schmid, Heribert Thaler, Histological grading and staging of chronic hepatitis. Journal of Hepatology. ,vol. 22, pp. 696- 699 ,(1995) , 10.1016/0168-8278(95)80226-6
Jamey D. Marth, Prabhjit K. Grewal, Mammalian glycosylation in immunity. Nature Reviews Immunology. ,vol. 8, pp. 874- 887 ,(2008) , 10.1038/NRI2417