Review: Sex-Based Differences in Treatment Outcomes for Persons With Opioid Use Disorder.

摘要: Background and objectives In order to address the current opioid crisis, research on treatment outcomes for persons with use disorder (OUD) should account biological factors that could influence individual response. Women men might have clinically meaningful differences in their experience OUD also unique challenges achieving successful, long-term recovery. This review summarizes synthesizes literature sex-based outcomes. Methods Relevant was identified via automated manual searches using terms "opioid outcome sex [or gender] differences" "opiate differences." Search methodology consistent Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA), were conducted within PubMed electronic database during March April of 2018. Results The initial search yielded 241 manuscripts 31 original articles met inclusion/exclusion criteria synthesized this review. Several important trends emerged, including findings women are more likely than present co-occurring mental health conditions such as depression, respond particularly well buprenorphine maintenance. Discussion conclusions While much topic is subject potential cohort effects, interventions psychosocial stress improve OUD. Scientific significance Funding agencies researchers focus attention toward human laboratory studies clinical trials prospectively designed assess (Am J Addict 2019;28:246-261).