Determination of oral tramadol pharmacokinetics in horses.
作者： S. Cox , N. Villarino , T. Doherty
DOI: 10.1016/J.RVSC.2010.02.011
关键词:
摘要: The determination of the pharmacokinetic parameters tramadol in plasma and a better characterization its metabolites after oral administration to horses is necessary design dosage regimens achieve target concentrations that are associated with analgesia. purpose this study was determine pharmacokinetics elimination pattern urine horses. Tramadol administered orally six half-life, T(max) C(max) were 10.1, 0.59 h, 132.7 ng/mL, respectively. for M1 4.0, 28.0 detectable between 1 24 h administration. In conclusion, PK data reported provides information future studies
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T. Bergan, A. Dalhoff, R. Rohwedder, Pharmacokinetics of ciprofloxacin. Infection. ,vol. 16, ,(1988) , 10.1007/BF01650500
A R. Moore, J H. McQuay, Single-patient data meta-analysis of 3453 postoperative patients: oral tramadol versus placebo, codeine and combination analgesics Pain. ,vol. 69, pp. 287- 294 ,(1997) , 10.1016/S0304-3959(96)03291-5
Stefan Grond, Thomas Meuser, Heinz Uragg, Hans J. Stahlberg, Klaus A. Lehmann, Serum concentrations of tramadol enantiomers during patient-controlled analgesia. British Journal of Clinical Pharmacology. ,vol. 48, pp. 254- 257 ,(1999) , 10.1046/J.1365-2125.1999.00986.X
Y. SHILO, M. BRITZI, B. EYTAN, T. LIFSCHITZ, S. SOBACK, A. STEINMAN, Pharmacokinetics of tramadol in horses after intravenous, intramuscular and oral administration. Journal of Veterinary Pharmacology and Therapeutics. ,vol. 31, pp. 60- 65 ,(2007) , 10.1111/J.1365-2885.2007.00929.X
Robert B. Raffa, Jeffry L. Vaught, Richard P. Shank, Ellen E. Codd, Elmar Friderichs, Wolfgang Reimann, Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. Journal of Pharmacology and Experimental Therapeutics. ,vol. 260, pp. 275- 285 ,(1992)
Vangala Subrahmanyam, Alfred P. Tonelli, David G. Walters, Brian G. Lake, Anthony B. Renwick, Roger J. Price, Philip J. Young, Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes. Drug Metabolism and Disposition. ,vol. 29, pp. 1146- 1155 ,(2001)
Robert B. Raffa, Richard P. Shank, N. Selve, Elmar Friderichs, H. I. Jacoby, J. L. Vaught, Wolfgang Reimann, E. E. Codd, Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol. Journal of Pharmacology and Experimental Therapeutics. ,vol. 267, pp. 331- 340 ,(1993)
Peter G. Welling, Interactions Affecting Drug Absorption Clinical Pharmacokinectics. ,vol. 9, pp. 404- 434 ,(1984) , 10.2165/00003088-198409050-00002
Lars Poulsen, Lars Arendt-Nielsen, Kim Brøsen, Søren H. Sindrup, The hypoalgesic effect of tramadol in relation to CYP2D6 Clinical Pharmacology & Therapeutics. ,vol. 60, pp. 636- 644 ,(1996) , 10.1016/S0009-9236(96)90211-8
B. KuKanich, M. G. Papich, Pharmacokinetics of tramadol and the metabolite O-desmethyltramadol in dogs. Journal of Veterinary Pharmacology and Therapeutics. ,vol. 27, pp. 239- 246 ,(2004) , 10.1111/J.1365-2885.2004.00578.X