Surgical management of isolated retroperitoneal recurrences of colorectal carcinoma.

摘要: PURPOSE: Isolated locoregional disease accounts for approximately 20 percent of recurrences after treatment colorectal cancer. It has been suggested that complete resection these can result in increased survival. The value surgery isolated retroperitoneal not well defined. We have sought to characterize outcome and survival patients undergoing METHODS: From a prospective database, 25 were identified as having undergone surgical exploration with curative intent cancer between 1988 1999. Variables studied included age, gender, location size the tumor, extent resection, disease-free interval, morbidity mortality. Statistical analyses performed using log-rank test Kaplan-Meier estimates, overall primary end point. RESULTS: study population consisted (13 males), median age 55 years follow-up 29 (range, 1–151) months. time first recurrence was 23 3–72) Twenty underwent whereas five deemed unresectable at operation. who 31 months compared 3 those did undergo (P = 0.0001). Analysis entire group demonstrated interval greater than 24 be positive predictor (median survival, 30 vs. 48 months; P 0.02). For presence margins 0.01) tumor ≥5 cm 0.008) predicted worse prognosis. In two-year five-year rates 60 15 percent, respectively. CONCLUSIONS: Patients generally poor However, longer negative-margin smaller are associated long-term selected patients.