TRIF‐dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target

摘要: Toll/IL-1R domain-containing adaptor-inducing IFN-β (TRIF)-dependent signaling is required for TLR-mediated production of type-I IFN and several other proinflammatory mediators. Various pathogens target the molecules transcriptional regulators acting in TRIF pathway, thus demonstrating importance this pathway host defense. Indeed, contributes to control both viral bacterial through promotion inflammatory mediators activation antimicrobial responses. also has protective pathologic roles chronic disease conditions, as well an essential function wound-repair processes. Here, we review our current understanding regulatory mechanisms that TRIF-dependent TLR signaling, role different infectious noninfectious states, potential manipulating therapeutic benefit.