In Vitro Activity of Caspofungin against Candida albicans Biofilms

摘要: Most manifestations of candidiasis are associated with biofilm formation on biological or inanimate surfaces. Candida albicans biofilms recalcitrant to treatment conventional antifungal therapies. Here we report the activity caspofungin, a new semisynthetic echinocandin, against C. biofilms. Caspofungin displayed potent in vitro sessile cells within biofilms, MICs at which 50% were inhibited well drug's therapeutic range. Scanning electron microscopy and confocal scanning laser used visualize effects caspofungin preformed results indicated that affected cellular morphology metabolic status The coating biomaterials had an inhibitory effect subsequent development by albicans. Together these findings indicate displays merits further investigation for biofilm-associated infections.