Mesenchymale Stromazellen auf dem Weg zur klinischen Anwendung: Update 2018
作者： Markus Rojewski , Richard Schäfer , Karin Bieback , Hubert Schrezenmeier , Halvard Bönig
DOI: 10.1055/A-0610-9685
关键词:
摘要: Mesenchymale Stromazellen (MSC) besitzen ein groses therapeutisches Potenzial sowohl fur Immunmodulation als auch regenerative Therapie. In einigen Indikationen, z. B. Behandlung der schweren Transplantat-gegen-Empfanger-Reaktion nach allogener Stammzelltransplantation, wurden MSC schon vor mehr 10 Jahren therapeutisch eingesetzt. weiteren Indikationen haben die in den letzten nun das Stadium klinischen Erprobung erreicht. Hier erfolgt eine Evaluation Sicherheit und Wirksamkeit einer MSC-Therapie einem sehr breiten Spektrum von Erkrankungen. Diese Ubersichtsarbeit stellt aktuellen Stand praklinischen Forschung zur Anwendung Transplantat-gegen-Empfanger-Reaktion, Wundheilungsstorungen, neurodegenerativen Erkrankungen Knochen- Knorpeldefekten dar.
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