Low dose of homoharringtonine and cytarabine combined with granulocyte colony-stimulating factor priming on the outcome of relapsed or refractory acute myeloid leukemia

作者: Liu-Fang Gu , Wang-Gang Zhang , Fang-Xia Wang , Xing-Mei Cao , Yin-Xia Chen

DOI: 10.1007/S00432-010-0947-Z

关键词:

摘要: Background To explore the effect of low dose homoharringtonine (HHT) and cytarabine (Ara-c) combined with granulocyte colony-stimulating factor (G-CSF) priming (HAG regimen) on relapsed or refractory acute myeloid leukemia (AML).

参考文章(42)
H Sakuma, S Furusawa, K Saito, K Yamada, H Yamato, A Aoyagi, S Tsunogake, K Waga, T Koike, H Arimura, Concurrent use of granulocyte colony-stimulating factor with low-dose cytosine arabinoside and aclarubicin for previously treated acute myelogenous leukemia: a pilot study. Leukemia. ,vol. 9, pp. 10- 14 ,(1995)
S. S. Legha, M. Keating, S. Picket, Michael S Ewer, G. P. Bodey, J. A. Ajani, Phase I clinical investigation of homoharringtonine. Cancer treatment reports. ,vol. 68, pp. 1085- 1091 ,(1984)
Lin Mao-fang, YE Xiu-jin, Homoharringtonine induces apoptosis of endothelium and down-regulates VEGF expression of K562 cells Journal of Zhejiang University Science. ,vol. 5, pp. 230- 234 ,(2004) , 10.1007/BF02840929
K Waga, J Tadokoro, A Aoyagi, M Aoyagi, H Arai, K Saito, Y Nakamura, W Takahashi, Y Arai, S Furusawa, F Inoue, K Yamamoto, T Handa, H Gunnji, Y Kawagoe, Y Kitsukawa, S Tsurumi, Low-dose cytarabine and aclarubicin in combination with granulocyte colony-stimulating factor (CAG regimen) for previously treated patients with relapsed or primary resistant acute myelogenous leukemia (AML) and previously untreated elderly patients with AML, secondary AML, and refractory anemia with excess blasts in transformation. International Journal of Hematology. ,vol. 71, pp. 238- 244 ,(2000)
Manuel FRESNO, Antonio JIMENEZ, David VAZQUEZ, Inhibition of Translation in Eukaryotic Systems by Harringtonine FEBS Journal. ,vol. 72, pp. 323- 330 ,(1977) , 10.1111/J.1432-1033.1977.TB11256.X
Yuzuru Takemura, Takao Ohnuma, Ting-Chao Chou, Tsuyoshi Okano, JamesF. Holland, Biologic and pharmacologic effects of harringtonine on human leukemia-lymphoma cells Cancer Chemotherapy and Pharmacology. ,vol. 14, pp. 206- 210 ,(1985) , 10.1007/BF00258117
Amuguleng Bai, Hiroshi Kojima, Mitsuo Hori, Nobuo Nara, Takuya Komeno, Yuichi Hasegawa, Haruhiko Ninomiya, Tsukasa Abe, Toshiro Nagasawa, Priming with G-CSF effectively enhances low-dose Ara-C-induced in vivo apoptosis in myeloid leukemia cells. Experimental Hematology. ,vol. 27, pp. 259- 265 ,(1999) , 10.1016/S0301-472X(98)00041-1
M. Hänel, K. Friedrichsen, A. Hänel, R. Herbst, A. Morgner, S. Neser, M. Nicklisch, M. Teich, G. Ehninger, F. Fiedler, Mito-flag as salvage therapy for relapsed and refractory acute myeloid leukemia. Onkologie. ,vol. 24, pp. 356- 360 ,(2001) , 10.1159/000055107
J. M. Li, Y. Shen, D. P. Wu, H. Liang, J. Jin, F. Y. Chen, Y. P. Song, e Y. P. Song, X. F. Qiu, M. Hou, Z. C. Qiu, Z. X. Shen, Aclarubicin and Low-Dose Cytosine Arabinoside in Combination with Granulocyte Colony-Stimulating Factor in Treating Acute Myeloid Leukemia Patients with Relapsed or Refractory Disease and Myelodysplastic Syndrome : A Multicenter Study of 112 Chinese Patients International Journal of Hematology. ,vol. 82, pp. 48- 54 ,(2005) , 10.1532/IJH97.A10424