Significance of granulomatous inflammation in usual interstitial pneumonia

摘要: Sarcoidosis is a systemic granulomatous disease of unclear etiology with characteristic pulmonary lesions. We describe 2 unique cases sarcoidosis where after approximately 20 years clinical quiescence, patients developed interstitial opacities on chest CT scan and an increase in shortness breath. With lack therapeutic response to course prednisone, both underwent surgical lung biopsy that revealed pattern consistent Usual Interstitial Pneumonia (UIP) honeycombing fibroblastic foci. Postoperatively, the was what would be expected Idiopathic Pulmonary Fibrosis. Ultimately progressed one patient needed transplantation other requiring high-flow oxygen supplementation. In conclusion, we present two whom diagnosis preceded UIP by or more. The subsequent Fibrosis (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 160-166)