Exaggerated pulmonary vascular response to acute hypoxia in older men

摘要: What is the central question of this study? Pulmonary arterial pressure higher in older than younger humans and predicts mortality. It also increased by acute hypoxia, which causes constriction pulmonary vasculature. We asked whether vascular response to hypoxia greater humans. main finding its importance? Using Doppler echocardiography 12 (∼ 20 years old) nine men 55 exposed min moderate isocapnic we demonstrated that showed a significantly rise during alveolar men. Future studies should examine pathophysiological importance hypoxic vasoconstriction with age. Resting increases age In general population, values are associated mortality, common cardiopulmonary diseases, such as congestive heart failure chronic obstructive disease, presence hypertension portends worse outcome. consequence hypothesized have more vigorous Twelve (20.5 ± 0.5 (55.8 2.1 were for on different days (end-tidal PO2 = 50 mmHg) euoxia 100 mmHg); each was preceded (baseline) followed 5 euoxia. Systolic cardiac output measured continuously using echocardiography. baseline euoxic measurements participants (27.8 0.8 versus 24.1 0.7 mmHg, P 0.001) (15.2 1.3 9.6 0.9 0.011). Cardiac did not differ between two groups (P 0.60) or 0.49). All data means SEM. The magnitude has implications individuals wishing ascend high altitude travel air, those suffering from conditions global feature patients requiring anaesthesia.