C-Reactive Protein and Body Mass Index Independently Predict Mortality in Kidney Transplant Recipients

摘要: C-reactive protein (CRP) is a risk factor for cardiovascular outcomes and mortality in the general population. To date, there are no prospective studies of association between CRP or allograft loss kidney transplant recipients (KTR). In 1995, 438 consecutive KTR were enrolled this study. Important information on demographic, clinical immunological characteristics was collected at baseline, measured using standard methods. Patients then followed-up median 7.8 years. Time-to-event analyses (univariate multivariate Cox proportional hazards regression models) used to study main outcomes: all-cause loss, defined as earlier return dialysis, re-transplantation, death. From univariate analyses, we found that ≥0.5 mg/dL associated with 83% greater compared lower levels inflammatory marker [hazard ratio (HR) = 1.83; 95% confidence interval (CI): 1.23–2.72; p 0.003]. After adjustment, patients had 53% higher whose below threshold (HR 1.53; CI: 1.01–2.31; 0.04). No associations detected. Furthermore, not able detect any effect modification body mass index under We conclude predicts mortality, but stable KTR.