Functional Role of Chromogranins
作者： Ricardo Borges , José D. Machado , Carmen Alonso , Miguel A. Brioso , José F. Gómez
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摘要: Chromaffin granules store catecholamines (CA) at very high concentrations, 0.5 to 1 M (Jankowski et al 1993b, Albillos 1997). Other soluble components, such as ATP, Ca2+, ascorbic acid, opiates, dopamine-h and it is believed that both the free bound CA are in equilibrium. It has been proposed chromogranin A (CGA) ATP promote passive aggregation of substances forming so-called intragranular matrix (Helle 1990). Several laboratory manoeuvres have developed study nature this "passive" interaction between components. Recently, we CA-CGs more complex than a simple process
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