Application of CXCR4 Inhibitors in Leukemia

摘要: Hematopoietic and cancer cells express the CXCR4 receptor, which in conjunction with its SDF-1/CXCL12 ligand mediates leukemia cell trafficking homing to marrow microenvironment. This interaction brings CXCR4-bearing within close proximity stromal cells, thus providing a niche for leukemic growth contributing drug resistance. Historically, antagonists were developed treatment of human immunodeficiency virus (HIV), but also found induce leukocytosis upon administration. led their use hematopoietic stem mobilization. However, since plays key role retention normal as well other microenvironments, may provide novel therapeutic approach interrupt these protective interactions sensitize AML blasts chemotherapy vivo. Preclinical and/or clinical studies have shown that drugs mobilize both progenitors into peripheral circulation they are synergistic G-CSF. In this chapter we will discuss inhibitors effects on mobilizing when given alone or G-CSF preclinical models clinic.