Polymorphisms and haplotypes in the cytochrome P450 17A1, prolactin, and catechol-O-methyltransferase genes and non-Hodgkin lymphoma risk.

摘要: Expression of prolactin and estrogen receptors in lymphocytes, bone marrow, lymphoma cell lines suggests that hormonal modulation may influence risk. Prolactin promote the proliferation survival B cells, factors increase non-Hodgkin risk, effects be modified by catechol-O-methyltransferase (COMT), an enzyme alters estrogenic activity. Cytochrome P450 17A1 (CYP17A1), a key biosynthesis, has been associated with increased cancer risk affect susceptibility. We studied polymorphisms (PRL) -1149G>T, CYP17A1 -34T>C, COMT 108/158Val>Met, predicted haplotypes among subset participants (n = 308 cases, n 684 controls) San Francisco Bay Area population-based study 1,593 2,515 conducted from 1988 to 1995. Oral contraceptive other hormone use also was analyzed. Odds ratios (OR) for follicular were reduced carriers PRL -1149TT genotype [OR, 0.64; 95% confidence interval (95% CI), 0.41-1.0; OR, 0.53; CI, 0.26-1.0, respectively]. Diffuse large-cell those including -34CC (OR, 2.0; 1.1-3.5). ORs all women decreased IVS1 701A>G [rs737865; variant allele: 0.34-0.82; 0.42; 0.23-0.78, Compared never users oral contraceptives, 35% observed total population. Reduced exogenous estrogens genotyped although CIs included unity. These results suggest PRL, CYP17A1, relevant genetic loci indicate possible role pathogenesis.