Stable iron isotope tracing reveals significant brain iron uptake in adult rats.

摘要: Iron deposits in the brain are a common hallmark of Alzheimer's disease and Parkinson's disease. This has spurred hypothesis that iron may play functional role pathogenesis neurodegenerative disorders through free radical damage. Previous short-term studies using radiotracers suggested uptake is small as compared to other tissues adult rodents. led assumption must also be marginal humans after development complete. In this study we applied novel approach determine directly fraction was transferred over time from diet organs rats. A known amount stable isotope (57Fe) fed with drinking water rats 4 months. Uptake tracer final content were assessed by Negative Thermal Ionization Mass Spectrometry (NTI-MS). We found only very dietary entered (0.000537 ± 0.000076%). amount, however, considerable relative total (9.19 0.71%), which lower but comparable percentage tissues. Whereas it remains unclear whether excessive intake risk factor diseases or high systemic correlates brain, our suggests much higher than previously thought. finding challenges current beliefs points possible nutrition disorders.