Piggy-backing the concept of cancer drugs for schistosomiasis treatment: a tangible perspective?

摘要: The fear that schistosomes will become resistant to praziquantel (PZQ) motivates the search for alternatives treat schistosomiasis. Recent studies of signaling proteins in uncovered a way achieving this goal relatively quickly. It was shown protein kinases (PKs) control important biological processes schistosomes. Concurrently, involvement mutant forms PKs demonstrated etiology cancer. Therefore, different anticancer drugs have been developed inhibit deregulated PKs. These can also schistosome PKs, thus blocking parasite development. characterizing are summarized and we discuss concept PK inhibitors, including approved cancer drugs, as novel candidate anti-schistosome agents. This is likely be significance other worm infections.