Primary Treatment Response Rather than Front Line Stem Cell Transplantation Is Crucial for Long Term Outcome of Peripheral T-Cell Lymphomas

摘要: Outcome of systemic peripheral T-cell lymphomas (PTCL) is unsatisfactory and no controlled clinical study guides the therapy. Phase II studies suggest to consolidate response achieved after front-line treatment with stem cell transplant (SCT). We retrospectively evaluate impact SCT consolidation in a single Center cohort 209 patients treated during last two decades. Median age was 49 years (range 15-85) prevalence male sex (61%), advanced stage (68%) while IPI >2 44%. Primary MACOP-B (39%) CHO(E)P (39%), intensive regimens (18%) or others (4%). Complete primary (i.e. before SCT) 60% (5% partial remission). Forty-four further proceeded 92 did not receive consolidation. responders good, 3-year overall survival 74% (82% ALCL ALK+ 69% for other histologies). By multivariate analysis better significantly associated IPI<2 (P=0.001), (P=0.000), (P=0.012). The performed on responders, showed that only predictive undergoing were not. Response rather than post-remission programs crucial determinant PTCL outcome.