Safety of Human Neural Stem Cell Transplantation in Chronic Spinal Cord Injury
作者： Katja M. Piltti , Desiree L. Salazar , Nobuko Uchida , Brian J. Cummings , Aileen J. Anderson
关键词:
摘要: The spinal cord injury (SCI) microenvironment undergoes dynamic changes over time, which could potentially affect survival or differentiation of cells in early versus delayed transplantation study designs. Accordingly, assessment safety parameters, including cell survival, migration, fate, sensory fiber sprouting, and behavioral measures pain sensitivity animals receiving transplants during the chronic postinjury period is required for establishing a potential therapeutic window. goal was parameters human central nervous system-derived neural stem (hCNS-SCns) by comparing hCNS-SCns subacute period, 9 days (DPI), 60 DPI, contusion-injured athymic nude rats. Although number surviving after lower, no migration were detected between DPI cohorts; however, data suggest may have enhanced generation mature oligodendrocytes. timing did not induce allodynia hyperalgesia measures. Together, these support post-SCI.
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