Distribution of Cell Adhesion Molecules (CAM) along the Branching Neurite Surface: Model-Inherited Effects of the Branch Diameters and Mode of CAM Transport

摘要: In many cases, an increase in the surface density of cell adhesion molecules (CAM) distal parts a growing neurite is favorable for elongation. This attained by exocytotic insertion CAM-containing vesicles into growth cones with subsequent redistribution CAM along due to lateral diffusion and endocytosis. Using mathematical model describing these processes, we quantitatively describe conditions providing two qualitatively different profiles branching neurite: (i) increases both daughter branches, which would be favor further outgrowth i.e., successful branching, or (ii) one branch decreases another branch, could lead retraction latter. The geometric factors mechanisms underlying intracellular transport were proved determine profile density. A similarity diameters their short lengths, high value transfer constant, partitioning at point proportionally areas branches are branches. Asymmetric can decrease thinner thicker if trafficking was equally partitioned proportional cross-sectional areas, respectively. proposed helps understand possible relationships between trafficking, distribution, geometry neurites.