Tissue distribution of lidocaine in critical care patients after intubation

摘要: Abstract We investigated tissue distribution of lidocaine in 33 patients after endotracheal intubation with Xylocaine™ jelly that contains 2% hydrochloride. Blood levels monoethylglycinexylidide (MEGX), an active metabolite lidocaine, were also determined. Five (Group A) alive on arrival and six B) resumed heartbeats cardiopulmonary resuscitation (CPR). The survival times for Groups A B ranged from 3 to 72 h. remaining 22 C) did not survive arrest (CPAOA). Systemic was measured nine Group C. liver-to-kidney ratios cerebrum-to-cerebrospinal fluid were: A, 0.1–0.7 1.4–3.6, respectively; B, 0.2–0.8 1.2–2.3, C, 0.1–17 0.2–1.0, respectively. MEGX detected all blood samples only two B. No Our results indicate the absorption tracheal during natural circulation a ratio 1.2 or more, whereas artificial by cardiac massage gives 1.0 less. may be more useful index estimate circulatory dynamics CPR than ratio. parameter monitoring changes massage.