Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association.

摘要: Insights from prospective, longitudinal studies of individuals at risk for developing type 1 diabetes have demonstrated that the disease is a continuum progresses sequentially variable but predictable rates through distinct identifiable stages prior to onset symptoms. Stage defined as presence β-cell autoimmunity evidenced by two or more islet autoantibodies with normoglycemia and presymptomatic, stage 2 dysglycemia 3 symptomatic disease. Adoption this staging classification provides standardized taxonomy will aid development therapies design clinical trials prevent disease, promote precision medicine, provide framework an optimized benefit/risk ratio impact regulatory approval, reimbursement, adoption interventions in early