Oral lesions of a patient with antidesmoglein 1 antibody-positive and antidesmoglein 3 antibody-negative pemphigus: Report of a case☆
作者： Yoshinori Jinbu , Akiko Kashiwazaki , Norikazu Munemasa , Michiko Ozawa , Mikio Kusama
DOI: 10.1016/J.AJOMS.2013.10.004
关键词:
摘要: Abstract The patient was a 47-year-old female who presented with skin and oral mucosal lesions. Edematous erythema pigmentation crusts were observed on the sinciput, precordium upper back, gingival erosion redness seen in cavity. Clinically, pemphigus vulgaris (PV) suspected. However, blood examination results positive for antidesmoglein 1 antibody, but negative anti-Dsg 3 antibody. Histopathological direct immunofluorescence microscopic observation revealed superficial vesicular formation IgG C3 deposits epithelial cell membranes. A diagnosis of foliaceus (PF) made. Regarding lesions, histopathological cleavage suprabasal layer detected, microscopy found intercellular almost entire layer. These findings compatible PV. As there contradiction between clinical features laboratory data, we further performed immunoblotting analysis. Autoantibodies against periplakin C-terminal 180-kDa bullous pemphigoid antigen (BP 180) detected. these autoantibodies not considered to pathogenic. We report rare case antibody-positive
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