Loss of CO2 sensing by the olfactory system of CNGA3 knockout mice
作者： Jinlong Han , Minmin Luo
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摘要: Atmospheric CO2 can signal the presence of food, predators or environmental stress and trigger stereotypical behav- iors in both vertebrates invertebrates. Recent studies have shown that necklace olfactory system mice sensitively de- tects air. Olfactory neurons are believed to rely on cyclic guanosine monophosphate (cGMP) as key second messenger; however, specific ion channel underlying responses remains unclear. Here we show CO2-evoked neu- ronal behavioral require nucleotide-gated (CNG) channels consisting CNGA3 subunit. Through Ca 2+ -imaging, found CO2-triggered influx was abolished sensory (OSNs) CNGA3-knockout mice. detection tests using a Go/No-go paradigm showed these knockout failed detect 0.5% CO2. Thus, sensitive atmospheric depends function CNG subunit OSNs. These data support important role sensing extend our understanding transduction pathway mediating mammals (Current Zoology 56 (6): 793-799, 2010).
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