Influence of corticosterone on growth, home-cage activity, wheel running, and aerobic capacity in house mice selectively bred for high voluntary wheel-running behavior.

摘要: Abstract Glucocorticoids, a class of metabolic hormones, impact wide range traits (e.g., behavior, skeletal growth, muscle maintenance, glucose metabolism), and variation in concentrations circulating glucocorticoids (such as corticosterone), at the level natural individual variation, relation to endocrine disorders, or from exogenous supplementation, have manifold effects. Changes corticosterone can also multiple aspects locomotor including both motivation physical ability for exercise. To examine further role behavior associated traits, we utilized laboratory house mice long-term experiment that selectively breeds high levels voluntary As compared with four non-selected control (C) lines, replicate High Runner (HR) lines ~2-fold higher baseline well ~3-fold wheel running on daily basis, home-cage activity when deprived wheels, maximal aerobic capacity, smaller body size; potentially, all these differences could be modulated by corticosterone. We administered 50 μg/mL corticosterone-21-hemisuccinate drinking water HR C male weaning through ~8 weeks age. had endogenous levels; wheel-running distance, duration, speed; oxygen consumption during forced exercise (VO2max); spent more time closed arms an elevated plus maze; larger reproductive fat pads. For mice, treatment strongly suppressed levels, decreased growth rate adult mass, increased food (both adjusted mass), entries into maze, (total average intensity), distance maximum speed, VO2max. At suborganismal level, relative adrenal, liver, triceps surae tail length, but subdermal pad masses, hematocrit. Overall, responses supplementation were “negative” health perspective. These results significant implications understanding evolution stress-related effects levels. They suggest patients experiencing extended periods glucocorticoid might benefit attempts increase their adjuvant.