Structure of a Type II Thymidine Kinase with Bound Dttp

摘要: The structure of human cytosolic thymidine kinase in complex with its feedback inhibitor 2′-deoxythymidine-5′-triphosphate was determined. This is the first representative type II kinases found several pathogens. deviates strongly from known structures I such as Herpes simplex enzyme. It contains a zinc-binding domain four cysteines complexing structural zinc ion. Interestingly, backbone atoms enzyme bind thymine via hydrogen-bonds, contrast to I, where side chains are involved. results specificity difference exploited for antiviral therapy. presented will foster development new drugs and prodrugs numerous therapeutic applications.