Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies

摘要: Epigenetic variations in peripheral blood have potential as biomarkers for disease. This systematic review assesses the association of lung function and chronic obstructive pulmonary disease (COPD) with DNA methylation profiles from population-based studies. Online databases Medline, Embase, Web Science were searched. Google Scholar was searched to identify grey literature. After removing duplicate articles, 1155 articles independently screened by two investigators. Peer reviewed reports on studies that examined participants measured (FEV1, FEV1/FVC ratio) or known COPD status selected full-text review. Six suitable inclusion. Information regarding study characteristics, designs, methodologies conclusions extracted. A narrative synthesis performed based published results. Three six assessed methylation, these also included associations function. Overall, five profiles. Five reported ‘significant’ However, no consistent CpG sites identified across values. patterns individuals reduced may be different those people normal this did not find any differentially methylated sites. Large a longitudinal design address reverse causality prove more fruitful area research. PROSPERO 2016: CRD42016037352 .