Antimutagenic effect of resveratrol against Trp-P-1
作者： Fukuji Uenobe , Sei-ichi Nakamura , Mitsuo Miyazawa
DOI: 10.1016/S0027-5107(96)00191-1
关键词:
摘要: The methanol extract of Yucca schidigera (YE) showed a suppressive effect on umu gene expression the SOS response induced by 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) in Salmonella typhimurium TA1535/pSK1002. YE was also observed for 2-aminoanthracene and activated Trp-P-1, without significant bacterial growth. exhibited weak SOS-induction N-methyl-N'-nitro-N-nitrosoguanidine, but not furylfuramide or 4-nitroquinoline-1-oxide. antimutagenic activity against Trp-P-1 demonstrated Ames assay using TA98. Isolation purification active component carried out SiO2 column chromatography, 275 mg compound isolated from 2.5 kg dried chips yucca roots branches. identified as 3,4',5-trihydroxystilbene (THS). suppression antimutagenicity THS determined test test.
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