Diagnostic and Prognostic Significance of Tumor Angiogenesis

摘要: The significance of tumor angiogenesis has been recognized for many centuries. Fallopio in the 1600s stated “cancers have dilated swollen veins resembling legs a crab, and this I single out from signs since if its cure is undertaken man nevertheless dies same cancer.” However, it only turn century that continual widespread research performed, was not until 1970s when Folkman colleagues aroused interest pathological first attempt made to generate systematic method quantifying angiogenesis. score based on assessment several morphological parameters “endothelial cell regeneration” stained by routine histological methods. Named MAGS (Microscopic Angiogenesis Grading System), assessed number vessels, degree endothelial-cell hyperplasia, cytology endothelium (1). aim develop an objective neovasculature could be used as standard reasearch, compare with other clinicopathological characteristics useful development efficacy anti-angiogenic agents vascular targeting therapies (2). difficulties still impede clinical utility quantitation systems today, including problems tissue-sample selection, inter- intraobserver variation, were such technique adopted. Further attempts assess carried using variety nonspecific endothelial markers but last five years, advent highly specific (3–5) can archival tissues, studies performed. As indicated earlier, there are limitations current methodologies measuring new methods continually being (see below). Furthermore, these mght potential supplementary uses diagnosis, prediction treatment response, monitoring disease status. Such might also applied common debilitating diseases psoriasis, rheumatoid arthritis (RA), atherosclerosis, diabetic retinopathy where central process.