The Changing Face of Very Early-Onset Inflammatory Bowel Disease.

摘要: As pediatricians, we are fully aware that our patients not “little adults.” During childhood, the body undergoes remarkable developmental change, impacting all facets of medical care. Drugs metabolized differently, diseases may present in a unique manner, and pediatric recover from illness at different pace than adults. Although pathophysiologic basis inflammatory bowel disease (IBD) be similar between children adults, anticipated course rate complications clearly different. Given high mood disorders, need for early surgery, potential comorbidities, including growth pubertal delay, approach to with IBD must tailored meet their specific needs understood context progression.1–4 In order do this, first characterize contrast older discover salient differences would allow more personalized treatment. Oliva-Hemker et al this issue The Journal contributes task, describing presentation therapeutic requirements aged 1–5 years very early-onset (VEO)-IBD an teenage cohort 11–16 years.5