Assessment of the mutagenic, antimutagenic and cytotoxic activities of ethanolic extract of araticum (Annona crassiflora Mart. 1841) by micronucleus test in mice.
作者： JB. Vilar , FL. Ferreira , PH. Ferri , LA. Guillo , L. Chen Chen
DOI: 10.1590/S1519-69842008000100020
关键词:
摘要: A typical Brazilian plant, araticum (Annona crassiflora Mart.), is widely used in humans as therapeutic medicine to treat several diseases such diarrhea, rheumatism and syphilis. It contains acetogenins which present cytotoxic, antitumogenic, antiparasitic properties. In this study, mutagenic, antimutagenic cytotoxic effects of leaves ethanolic extract were evaluated by micronucleus test mice. To evaluate the mutagenic activity, animals treated with (EEA) using 10, 20, 50, 100 160 mg.kg(-1). For all doses, micronucleated polychromatic erythrocytes (MNPCE) frequency was at 24, 48 72 hours after treatment. 50 mg.kg(-1) EEA 4 MMC simultaneously. The MNPCE 36 exposure. Cytotoxicity normochromatic ratio (PCE/NCE). mutagenicity assessment, doses resulted no significant increase (P > 0.05), compared solvent- control group. Regarding administration time, difference among three evaluation periods observed 0.05). Such results indicate that did not exert activity. evident 24 Concerning antimutagenicity, except 10 co-administered mg/kg MMC, reduced significantly positive group < These results, therefore, an activity EEA. increased 0.01) MMC.
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