Neurochemical Aspects of Oxidative and Nitrosative Stress

作者: Akhlaq A. Farooqui

DOI: 10.1007/978-3-319-04111-7_6

关键词:

摘要: Oxidative stress, which is an imbalance between ROS and RNS production the ability of cells to eliminate them, caused by high levels RNS. Enhanced play a critical role in molecular mechanism neurodegeneration. Neurodegeneration not only RNS-mediated damage neural membrane phospholipid, proteins, nucleic acids, but also generation variety ARA-derived toxic lipid aldehyde species such as 4-hydroxynonenal (4-HNE), acrolein, malondialdehyde, IspP, IsoF, IsoK. Lipid mediators like 4-HNE contain more than one functional group, can participate Schiff base formation and/or Michael addition reactions. its glutathione conjugates have been shown regulate redox-sensitive transcription factors NF-κB AP-1 via signaling through various protein kinase cascades. promoted enhanced peroxynitrite

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