Analysis of lncRNA-mRNA expression pattern in male textile workers with noise-induced hearing loss
作者： Ning Wang , Xin Liu , Lu Ding , Enmin Ding , Baoli Zhu
关键词:
摘要: Background: Extracellular long non-coding RNA (lncRNA) has attracted increasing attention as a potential biomarker to indicate disease status and physiological process. It plays unique role in pathogenesis, may be new biomarker, especially for chronic hearing loss. Early screening of NIHL susceptible population is great significance reducing the incidence NIHL. Methods: The expression profiles lncRNAs mRNAs serum noise-induced loss (NIHL) exposure groups were detected by microarray technique serum. differentially expressed was analyzed GO KEGG identify related biological functions signaling pathways. top up-regulated down regulated identified qRT-PCR. Results: A total 2,072 (889 1,183 down-regulated) included subjects compared exposed group using microarrays. enrichment pathway analysis showed that pattern associated with noise exposure. LncRNAs verified qRT-PCR, namely, LOC101928211, LOC101928804, BANCR. LOC101928211 LOC101928804 significantly higher than group, while BANCR obviously decreased (P Conclusions: In this study, profile preliminarily investigated silico. newly discovered might involved pathological process serve biomarkers long-term exposure-induced
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