Height, Body Weight, and Risk of Prostate Cancer'

摘要: Using data from the Health Professionals Follow-Up Study, we prospectively examined relationships between height, body mass index, waist and hip circumferences, risk of total advanced (extraprostatic metastatic) prostate cancer. In addition, assessed adiposity during childhood, adolescence, early, middle, late adulthood using pictograms in relation to cancer risk. Between 1986 1994, 1,369 cases (excluding stage A1) were confirmed 47,781 men. Adult index circumferences not appreciably related or contrast, preadult (age 10) obesity 33,336 men 1988 was lower [relative (RR) = 0.72 with 95% confidence interval (CI) 0.47-1.10, high low quintiles; P(trend) 0.06] metastatic (RR 0.38 CI 0.19-0.77; 0.004). For lesions, an association observed height 1.68 1.16-2.43 for 74 inches taller, relative 68 shorter; 0.01). analysis limited particularly aggressive forms cancer, i.e., found be at time diagnosis 1994 after a negative digital rectal examination 1988, that ages 5 10 had strong inverse 0.16 0.05-0.54, quintiles age tallness direct disease 2.29 1.04-5.05, > versus < inches). Our findings suggest hormonal milieu, as reflected attained childhood obesity, may have influence on carcinogenesis.