Apoptosis and cancer risk assessment

摘要: Apoptosis is one form of physiological or active cell death. The balance between proliferation and death apoptosis not only effects organ growth but also has a profound impact on the net increase initiated cells preneoplastic tumor populations. With respect to cancer development becoming widely recognized as being an innate tissue defense against carcinogens by inhibiting survival controlling precancerous populations tumors at different stages carcinogenesis. Experimental data birth rates help identify mode action chemical can be incorporated into biologically based models. This article describes quantitation regulation in rodent liver how loss have role hepatocarcinogenesis. A biologically-based mouse model presented utilized describe treatment related affect process Advantages limitations models research risk assessment are discussed.