Heat Shock Transcription Factors: Structure and Regulation

摘要: Organisms respond to elevated temperatures and chemical physiological stresses by an increase in the synthesis of heat shock proteins. The regulation gene expression eukaryotes is mediated conserved transcription factor (HSF). HSF present a latent state under normal conditions; it activated upon stress induction trimerization high-affinity binding DNA exposure domains for transcriptional activity. Analysis cDNA clones from many species has defined structural regulatory regions responsible inducible activities. signal thought be transduced changes physical environment, activity HSF-modifying enzymes, or intracellular level