An overview of methods used to clarify pathogenesis mechanisms of Campylobacter jejuni.

摘要: Thermotolerant campylobacters are the most frequent cause of bacterial infection lower intestine worldwide. The mechanism pathogenesis Campylobacter jejuni comprises four main stages: adhesion to intestinal cells, colonization digestive tract, invasion targeted and toxin production. In response high number cases human campylobacteriosis, various virulence study models available according stage being analyzed. aim this review is compare different used look at disease. Molecular biology tools identify genes or proteins involved in mechanisms also summarized. Despite cost limited availability, animal frequently disease, particular analyze stage. Eukaryotic cell cultures have been developed because fewer restrictions on their use these compared with models, ex vivo approach makes it possible mimic cell-host interactions observed natural disease cases. Models complemented by molecular tools, especially mutagenesis DNA microarray methods putative permit characterization. No current model seems be ideal for studying complete range C. virulence. However, deal aspects complex pathogenic bacterium.