Variability in blood oxygen level dependent (BOLD) signal in patients with stroke-induced and primary progressive aphasia.

摘要: Although fMRI is increasingly used to assess language-related brain activation in patients with aphasia, few studies have examined the hemodynamic response function (HRF) perilesional, and contralesional areas of brain. In addition, relationship between HRF abnormalities other variables such as lesion size severity aphasia has not been explored. The objective this study was investigate changes signal during neural stroke-induced (SA). We also status due nonvascular etiology, namely, primary progressive (PPA). Five right handed SA patients, three PPA five healthy individuals participated study. Structural damage quantified T1-weighted MR images. Functional imaging performed long trial event-related design an overt naming task measure BOLD time peak (TTP) percent change (ΔS). average TTP significantly delayed left hemisphere regions involved compared participants patients. However, ΔS different two groups. Delay network correlated showed a negative correlation global language function. There were no significant differences homologues or occipital control across had normal pattern. Our results indicate that abnormal task-related primarily found raise possibility physiology superimposed on structural may contribute clinical deficit. Follow-up investigations larger sample age-matched individuals, SA, will be needed further confirm extend our findings.