Methods for protecting and regenerating bone marrow using CXCR3 agonists and antagonists
作者： Di Xiang , Wei Han , Huili Lu
DOI:
关键词:
摘要: CXCR3 agonists, including natural ligands, promote bone marrow regeneration, increase peripheral white blood cells, and survival if administered prior to treatment of a subject with chemotherapy or radiotherapy. Similar effects are obtained by administering an antagonists following Compositions methods presented for the cancer diseases.
lens.org 参考文章(14)
Anton V. Gorbachev, Hirohito Kobayashi, Daisuke Kudo, Charles S. Tannenbaum, James H. Finke, Suyu Shu, Joshua M. Farber, Robert L. Fairchild, CXC Chemokine Ligand 9/Monokine Induced by IFN-γ Production by Tumor Cells Is Critical for T Cell-Mediated Suppression of Cutaneous Tumors Journal of Immunology. ,vol. 178, pp. 2278- 2286 ,(2007) , 10.4049/JIMMUNOL.178.4.2278
Carlo Laudanna, Federica Calzetti, Sara Gasperini, Marco A. Cassatella, Joshua Farber, Henrik Olsen, Lucia Vicentini, Martina Marchi, Marianne Murphy, Fang Liao, Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils Journal of Immunology. ,vol. 162, pp. 4928- 4937 ,(1999)
J. Michael Ruehlmann, Stephen D. Gillies, Andreas G. Niethammer, Carrie S. Dolman, Ursula Pertl, Rong Xiang, Ralph A. Reisfeld, Yi Ba, MIG (CXCL9) Chemokine Gene Therapy Combines with Antibody-Cytokine Fusion Protein to Suppress Growth and Dissemination of Murine Colon Carcinoma Cancer Research. ,vol. 61, pp. 8498- 8503 ,(2001)
E. Lazzeri, P. Romagnani, CXCR3-binding chemokines: novel multifunctional therapeutic targets. Current Drug Targets - Immune, Endocrine & Metabolic Disorders. ,vol. 5, pp. 109- 118 ,(2005) , 10.2174/1568008053174723
R Zhang, L Tian, L-J Chen, F Xiao, J-M Hou, X Zhao, G Li, B Yao, Y-J Wen, J Li, L Zhang, X-C Chen, F Luo, F Peng, Y Jiang, Y-Q Wei, Combination of MIG (CXCL9) chemokine gene therapy with low-dose cisplatin improves therapeutic efficacy against murine carcinoma Gene Therapy. ,vol. 13, pp. 1263- 1271 ,(2006) , 10.1038/SJ.GT.3302756
J. M. Farber, A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 5238- 5242 ,(1990) , 10.1073/PNAS.87.14.5238
Tamara Loos, Lies Dekeyzer, Sofie Struyf, Evemie Schutyser, Klara Gijsbers, Mieke Gouwy, Annelies Fraeyman, Willy Put, Isabelle Ronsse, Bernard Grillet, Ghislain Opdenakker, Jo Van Damme, Paul Proost, TLR ligands and cytokines induce CXCR3 ligands in endothelial cells: enhanced CXCL9 in autoimmune arthritis Laboratory Investigation. ,vol. 86, pp. 902- 916 ,(2006) , 10.1038/LABINVEST.3700453
J. Gosling, F. S. Monteclaro, R. E. Atchison, H. Arai, C.-L. Tsou, M. A. Goldsmith, I. F. Charo, Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 5061- 5066 ,(1997) , 10.1073/PNAS.94.10.5061
Wei Han, Yan Yu, Xin Yuan Liu, Local signals in stem cell-based bone marrow regeneration. Cell Research. ,vol. 16, pp. 189- 195 ,(2006) , 10.1038/SJ.CR.7310026
James J. Yun, Michael P. Fischbein, David Whiting, Yoshihito Irie, Michael C. Fishbein, Marie D. Burdick, John Belperio, Robert M. Strieter, Hillel Laks, Judith A. Berliner, Abbas Ardehali, The Role of MIG/CXCL9 in Cardiac Allograft Vasculopathy American Journal of Pathology. ,vol. 161, pp. 1307- 1313 ,(2002) , 10.1016/S0002-9440(10)64407-0