Attenuated rabies virus with nucleoprotein mutation at the phosphorylation site for vaccination against rabies and gene therapy in the CNS
作者： Zhen Fang Fu
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摘要: A mutant virus is provided which contains a mutation at phosphorylation site in one or more of the proteins virus, causes to be attenuated, and therefore, an improved vaccine composition can produced therewith. The invention also relates compositions contain as well methods inducing immune response, protecting mammals from infection by rabies virus. Also included are producing viral proteins, including host cell produces even overproduces wild-type counterpart protein, complements other such that production particle optimized. includes those cells optimized, either alone combination with intact response mammal infection, using same. vectors suitable for delivering gene human animal, delivery thereof.
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