Towards a functional understanding of protein N-terminal acetylation.

摘要: Protein N-terminal acetylation is a major modification of eukaryotic proteins. Its functional implications include regulation protein–protein interactions and targeting to membranes, as demonstrated by studies handful Fifty years after its discovery, potential general function the acetyl group carried thousands unique proteins remains enigmatic. However, recent data suggest roles for degradation signal determining factor preventing protein secretory pathway, thus highlighting determinant life death These contributions represent new intriguing hypotheses that will guide research in come.