Synthesis of novel substituted pyrimidine derivatives bearing a sulfamide group and their in vitro cancer growth inhibition activity.
作者： Carole-Anne Lefebvre , Elsa Forcellini , Sophie Boutin , Marie-France Côté , René C.-Gaudreault
DOI: 10.1016/J.BMCL.2016.11.052
关键词:
摘要: The synthesis of two series novel substituted pyrimidine derivatives bearing a sulfamide group have been described and their in vitro cancer growth inhibition activities evaluated against three human tumour cell lines (HT-29, M21, MCF7). In general, activity has enhanced by the introduction bulky substituent on aromatic ring with best compound having GI50<6μM for all lines. MCF7 selective compounds were four additional invasive breast ductal carcinoma (MDA-MB-231, MDA-MB-468, SKBR3, T47D) T47D line cases except one, suggesting potential antiestrogen activity.
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