Protein cage nanostructure as drug delivery system: magnifying glass on apoferritin.

摘要: ABSTRACTIntroduction: New frontiers in nanomedicine are moving towards the research of new biomaterials. Apoferritin (APO), is a uniform regular self-assemblies nano-sized protein with excellent biocompatibility and unique structure that affords it ability to stabilize small active molecules its inner core.Areas covered: APO can be loaded by applying passive process (mainly used for ions metals) or formulative approach based on disassemby/reassembly process. In this article, we aim organize experimental evidence provided number studies loading, release targeting. Attention initially focused most investigated antineoplastic drug contrast agents up recent application gene therapy.Expert opinion: Various preclinical have demonstrated improved potency selectivity some chemotherapeutics. However, order translate use into therapy, issues must solved, especially regarding rep...