Flavodoxins as Novel Therapeutic Targets Against Helicobacter pylori and Other Gastric Pathogens

摘要: Flavodoxins are small soluble electron transfer proteins widely present in bacteria and absent vertebrates. participate different metabolic pathways and, some bacteria, they have been shown to be essential representing promising therapeutic targets fight bacterial infections. Using purified flavodoxin chemical libraries, leads can identified that block function act as bactericidal molecules, it has demonstrated for Helicobacter pylori (Hp), the most prevalent human gastric pathogen. Increasing antimicrobial resistance by this bacterium led current therapies lose effectiveness, so alternative treatments urgently required. Here, we summarize, with a focus on flavodoxin, opportunities pharmacological intervention offered potential protein described provide information other gastrointestinal pathogens also from gut microbiota contain flavodoxin. The process of discovery development novel antimicrobials specific Hp is being carried out our group explained, extrapolated inhibitors pathogens. high specificity developed may help reduce damage slow down resistant mutants.