作者: Gustavo Graciano Fonseca , Elmar Heinzle , Christoph Wittmann , Andreas K. Gombert
DOI: 10.1007/S00253-008-1458-6
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摘要: Strains belonging to the yeast species Kluyveromyces marxianus have been isolated from a great variety of habitats, which results in high metabolic diversity and substantial degree intraspecific polymorphism. As consequence, several different biotechnological applications investigated with this yeast: production enzymes (β-galactosidase, β-glucosidase, inulinase, polygalacturonases, among others), single-cell protein, aroma compounds, ethanol (including high-temperature simultaneous saccharification-fermentation processes); reduction lactose content food products; bioingredients cheese-whey; bioremediation; as an anticholesterolemic agent; host for heterologous protein production. Compared its congener model organism, lactis, accumulated knowledge on K. is much smaller spread over number strains. Although there no publicly available genome sequence species, 20% CBS 712 strain was randomly sequenced (Llorente et al. FEBS Lett 487:71–75, 2000). In spite these facts, can envisage future because some qualities, such broad substrate spectrum, thermotolerance, growth rates, less tendency ferment when exposed sugar excess, compared lactis. To increase our biology enable potential be converted into industrial practice, more systematic approach, including careful choice (a) reference strain(s) by scientific community, would certainly value.