Polymerization of the adenosine 5'-diphosphate-ribose moiety of nicotinamide-adenine dinucleotide by nuclear enzyme. I. Enzymatic reactions.
作者： Shinji Fujimura , Shuji Hasegawa , Yoshiko Shimizu , Takashi Sugimura
DOI: 10.1016/0005-2787(67)90043-3
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摘要: Abstract [8- 14 C]ATP was incorporated by a rat-liver nuclear preparation into acid-insoluble material in the presence of NMN. Experiments using variously labeled ATP and NMN or NAD revealed that ADP-ribose moiety reaction product. formed from an immediate precursor The involving incorporation had optimum pH 8 required neither divalent cation nor sulfhydryl compound. effectively inhibited nicotinamide but not isonicotinic acid hydrazide. contribution NADase nuclei towards this enzymatic activity suggested.
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