Decrease and recovery of N-acetylaspartate/creatine in rat brain remote from focal injury.
作者： Charles Gasparovic , Nariman Arfai , Nicole Smid , Dennis M Feeney , None
DOI: 10.1089/08977150151070856
关键词:
摘要: Magnetic resonance spectroscopy (MRS) studies on traumatic brain injury (TBI) have shown that the neuronal metabolite N-acetylaspartate (NAA) may be reduced in regions of remote from sites focal injury. Such reductions generally been attributed to diffuse axonal (DAI) or neuron death. The aim present study was investigate contribution metabolic depression, absence DAI cell death, NAA reduction after TBI. right sensorimotor cortices adult rats were injured by weight drop. Two and six days later, tissue slices ipsilateral occipital cortex, same region uninjured rats, superfused examined 1H-MRS. cortex has negligible death but marked transient depression this model injury, ratio peak height total creatine (NAA/TCr) 14% lower than control samples. Six NAA/TCr recovered...
liebertonline.com参考文章(38)
Tarun B. Patel, John B. Clark, Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport Biochemical Journal. ,vol. 184, pp. 539- 546 ,(1979) , 10.1042/BJ1840539
Atsuo Yoshino, David A. Hovda, Tatsuro Kawamata, Yoichi Katayama, Donald P. Becker, Dynamic changes in local cerebral glucose utilization following cerebral concussion in rats: evidence of a hyper- and subsequent hypometabolic state Brain Research. ,vol. 561, pp. 106- 119 ,(1991) , 10.1016/0006-8993(91)90755-K
Y. XIONG, Q. GU, P.L. PETERSON, J.P. MUIZELAAR, C.P. LEE, Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury. Journal of Neurotrauma. ,vol. 14, pp. 23- 34 ,(1997) , 10.1089/NEU.1997.14.23
William M. Brooks, Seth D. Friedman, Charles Gasparovic, Magnetic resonance spectroscopy in traumatic brain injury. Journal of Head Trauma Rehabilitation. ,vol. 16, pp. 149- 164 ,(2001) , 10.1097/00001199-200104000-00005
S. Kalra, D.L. Arnold, N.R. Cashman, Biological markers in the diagnosis and treatment of ALS. Journal of the Neurological Sciences. ,vol. 165, ,(1999) , 10.1016/S0022-510X(99)00023-4
William G Dail, Dennis M Fenney, Heather M Murray, Richard T Linn, Michael G Boyeson, None, Responses to cortical injury: II. Widespread depression of the activity of an enzyme in cortex remote from a focal injury Brain Research. ,vol. 211, pp. 79- 89 ,(1981) , 10.1016/0006-8993(81)90068-8
Michael P Weisend, Dennis M Feeney, None, The relationship between traumatic brain injury-induced changes in brain temperature and behavioral and anatomical outcome Journal of Neurosurgery. ,vol. 80, pp. 120- 132 ,(1994) , 10.3171/JNS.1994.80.1.0120
N. De Stefano, P. M. Matthews, B. Ford, A. Genge, G. Karpati, D. L. Arnold, Short‐term dichloroacetate treatment improves indices of cerebral metabolism in patients with mitochondrial disorders Neurology. ,vol. 45, pp. 1193- 1198 ,(1995) , 10.1212/WNL.45.6.1193
BO-YOUNG CHOE, TAE-SUK SUH, KYU-HO CHOI, K YUNG-SUB SHINN, CHUN-KUN PARK, JOON-KI KANG, Neuronal dysfunction in patients with closed head injury evaluated by in vivo 1H magnetic resonance spectroscopy. Investigative Radiology. ,vol. 30, pp. 502- 506 ,(1995) , 10.1097/00004424-199508000-00008
ROBERTO VAGNOZZI, ANTHONY MARMAROU, BARBARA TAVAZZI, STEFANO SIGNORETTI, DONATO DI PIERRO, FRANCO DEL BOLGIA, ANGELA MARIA AMORINI, GIOVANNA FAZZINA, SHAHRAM SHERKAT, GIUSEPPE LAZZARINO, Changes of cerebral energy metabolism and lipid peroxidation in rats leading to mitochondrial dysfunction after diffuse brain injury. Journal of Neurotrauma. ,vol. 16, pp. 903- 913 ,(1999) , 10.1089/NEU.1999.16.903