Magnetic resonance imaging of brain angiogenesis after stroke.

摘要: Stroke is a major cause of mortality and long-term disability worldwide. The initial changes in local perfusion tissue status underlying loss brain function are increasingly investigated with noninvasive imaging methods. In addition, there growing interest processes that contribute to post-stroke recovery. this review, we discuss the application magnetic resonance (MRI) assess formation new vessels by angiogenesis, which hypothesized participate plasticity functional recovery after stroke. excellent soft contrast, high spatial temporal resolution, versatility render MRI particularly suitable monitor dynamic involved vascular remodeling Here review recent advances field MR aimed at assessment microvascular characteristics, including cerebral blood flow volume, density, size integrity. potential noninvasively evolution post-ischemic angiogenic demonstrated from variety vivo studies experimental stroke models. Finally, some pitfalls limitations may critically affect accuracy interpretation MRI-based measures (neo)vascularization